Publications: (link to Harvard Catalyst Profile) 

1.    Neppl R.L., Wu C.L., Walsh K. (2017) lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell BiolAug 30.  pii: jcb.201612100. doi: 10.1083/jcb.201612100. 

2.    Neppl R.L., Wang D.Z. (2014) The myriad essential roles of microRNAs in cardiovascular homeostasis and disease. Genes Dis. Mar 1;1(1):18-39.

3.    Neppl R.L., Kataoka M., Wang D.Z. (2014) Crystallin-aB regulates skeletal muscle homeostasis via modulation of Argonaute2 activity. J Biol Chem. Jun 13;289(24):17240-8.                           

4.    Tao Y., Neppl R.L., Huang Z.P., Chen J., Tang R.H., Cao R., Zhang Y., Jin S.W., Wang D.Z.  (2011). The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.  J Cell Biol. 194: 551-565.

5.    Neppl R.L., Wang D.Z. (2011) ‘CArG’ing for microRNAs.  Gastroenterology.  141: 24-27.

6.    Zieba B.J., Artamonov M.V., Jin L., Momotani K., Ho R., Franke A.S., Neppl R.L., Stevenson A.S., Khromov A.S., Chrzanowska-Wodnicka M., Somlyo A.V. (2011) The cAMP responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down regulation of RhoA activity.  J Biol Chem. 286: 16681-16692.

7.    Neppl R.L., Hoofnagle M.H., Berzin E.L., Pipes G.C., Marshall K.D., Olson E.N., Wamhoff B.R., Somlyo A.V., Owens G.K. (2011) Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.  Am J Physiol Heart Circ Physiol. 300: H1707-H1721.

8.    Nguyen A., Xiao B., Neppl R.L., Kallin E., Li J., Chen T., Wang D.Z., Xiao X., Zhang Y. (2011) Dot1l regulates dystrophin expression and is critical for cardiac function. Genes Dev. 25: 263-274.

9.  Huang Z.P., Neppl R.L., Wang D.Z. (2011) Chapter 12: Application of microRNAs in cardiac and skeletal muscle disease gene therapy.  Methods Mol Biol.  709: 197-210.

10.  Neppl R.L., Wang D.Z. (2010) MicroRNAs in cardiovascular disease.  Encyclopedia of Life Sciences (ELS).  [doi: 10.1002/9780470015902.a0022431]

11.  Huang Z.P., Neppl R.L., Wang D.Z. (2010) MicroRNAs in cardiac remodeling and disease. J Cardiovascular Translational Research.  3: 212-218.

12.  Neppl R.L., Wang D.Z. (2009) Smooth(ing) muscle differentiation by microRNAs.  Cell Stem Cell.  5:130-132.

13.  Neppl R.L., Lubomirov L.T., Momotani K., Pfitzer G., Eto M., Somlyo A.V. (2009) Thromboxane A2 induced bidirectional regulation of cerebral arterial tone.  J Biol Chem.  284: 6348-6360.

14.  Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A. (2008) Deletion of protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.    J Biol Chem. 283: 11850-11859.

15.  Sinha S., Wamhoff B.R., Hoofnagle M.H., Thomas J., Neppl R.L., Deering T., Helmke B.P., Bowles D.K., Somlyo A.V., Owens G.K. (2006) Assessment of Contractility of Purified Smooth Muscle Cells Derived from Embryonic Stem Cells.  Stem Cells. 24:1678-1688

16.  Neppl R., Nguyen C.M., Bowen W., Al-Saadi T., Pallagi J., Morris G., Mueller W., Johnson R., Prost R., Rand S.D. (2001) In vivo detection of postictal perturbations of cerebral metabolism by use of proton MR spectroscopy: preliminary results in a canine model of prolonged generalized seizures.  AJNR Am J Neuroradiol. 22:1933-1943.

17.  Butzen J., Prost R., Chetty V., Donahue K., Neppl R., Bowen W., Li S.J., Haughton V., Mark L., Kim T., Mueller W., Meyer G., Krouwer H., Rand S. (2000) Discrimination between neoplastic and non-neoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model.  AJNR Am J Neuroradiol. 21:1213-1219.